In the year 2020, events finally come full-circle as Echo and the few surviving Dollhouse staff struggle to restore mankind after the devastating events seen in the first season episode, "Epitaph" that has turned 90% of Earth's population into mindless, kill-crazy zombies out to kill those not infected (called 'actuals') by the Rossum's remote mind-wipe system. In the meantime, fellow actuals, Mag, Zone, and the mind-restored Caroline set out to find the save haven that can save man-kind from total extinction.